Caecilia Sirengke
Caecilia Sirengke
Fakultas Farmasi, Universitas Mulawarman, Samarinda, Kalimantan Timur
Sabaniah Indjar Gama
Fakultas Farmasi, Universitas Mulawarman, Samarinda, Kalimantan Timur
Islamudin Ahmad
Fakultas Farmasi, Universitas Mulawarman, Samarinda, Kalimantan Timur
Kata kunci: Uncaria Nervosa Elmer, KCV, KK, KLT dan Subfraksi
Abstract
Bajakah (Uncaria Nervosa Elmer) is one of the plants that is empirically used by the people of the interior ofKalimantan as a traditional medicine which is believed to be able to treat various degenerative diseases such asdiabetes, cancer, tumors, and others. The purpose of this study was to determine secondary metabolites,fractionation techniques and antibacterial activity of the root of bajakah (uncarianervosa elmer). The identificationof secondary metabolites was carried out qualitatively. Separation of compounds was carried out using VacuumLiquid Chromatography (KCV), Conventional Column Chromatography (KK) with N-hexane: ethyl acetate aseluent (1:1) and preparative Thin Layer Chromatography (TLC) and then identified the separation using ThinLayer Chromatography (TLC). Antibacterial activity test using TLC Bioautography method. The secondarymetabolite test results showed that the root of the pirated fruit contained alkaloids, saponins, terpenoids, andphenolic compounds. The result of sub fractionation B1 is a phenolic group compound. Antibacterial activity testshowed that the ethyl acetate fraction and sub-fraction B1 of bajakah root had antibacterial activity in the presenceof an inhibitory zone against Escerichia coli and Staphylococcus aureus.
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Published
2021-12-31